Yes, calcium will precipitate out, I don't know about the rest of the chemicals, but I had purchased a hard rock IO saltmix and what I noticed on my mixing 25gallons container is that lots of white dust settle on the bottom, even if I left an skimmer pump for keep stirring the saltwater that won't dissolve anymore, however I have used almost all of that box and haven't had an issue, I'm just adding a CA solution to raise level where I wanted, even so I don't have any sps or clams nor calcium demand, but what I can see is purple coralline growth up. I think its just depends on your tank needs for choosing the right salt and the age of it.