How do you mean, exactly? Many skimmers use external pumps like that (venturis and beckett skimmers in particular...). Are you thinking of using one as a needlewheel or threadwheel for a recirculating skimmer? The answer is yes--it's quite easy to use one that way. I actually have an iwaki that I've mesh-modded. I just dremelled off the impeller to get a flat surface and glued on an acrylic disk, then drilled it in a few places and zip tied some mesh to it. I never did get a chance to use it on a skimmer, though...I had to steal it away to run my chiller...
You could make a pretty crude venturi and stick it on a 5gal water jug to see how it does (which has been done before). Limitless possibilities, really. The problem is these pumps are not all very efficient (some are--look at the Reeflo Dart needlewheel skimmer that has just come out), and you are usually better off going with a lower wattage pump like an OR3500, Ehiem, Sedra, etc...