On large tanks, acrylic is the best option and often times, the only option.
Your basics have been covered here: clarity, weight, etc.
Yes, acrylic is easier to scratch, but it's also easier to repair. Glass is nearly impossible to repair. I have a glass tank and it has scratches that'll never be fixed. My acrylic tank was pristine. Every time I did get a little scratch, I'd take care of it immediately. With the right filtration and maintenance, you shouldn't have a badly scratched acrylic tank.
Thermal properties: acrylic will insulate better than glass. Something to consider especially if you're planning for a basement tank.
Deflection: under spec'd acrylic will deflect a lot. Be wary of cheap tanks. Not only is the material thinner than it should be, it's generally a very low grade acrylic. This low grade acrylic will yellow rather quickly. Top quality acrylics are thicker, more dense, and do not yellow.
Whatever material you decide on, research the company you're dealing with (just like anything else). Make sure they're going to be there for you through thick and thin. As a hobbyist, I got stung plenty of times dealing with companies that left me hanging.