No such thing as a stupid question.

And like I said in the PM, posting them here helps others see the answers and may help them. Plus, others will join in with ideas that very well may be better than mine. (usually the case). LOL
1. I am using 1". Depending on the pump you choose you could go with 3/4" for that size of a tank. My thoughts were that I don't want to limit myself based on pipe size. Bigger is better in most cases. Besides, the bit I borrowed was sized for 1" bulkheads.

2. I am using 1/4" thick acrylic. It was scrape that came out of some electrical equipment and I got it for free. Hard to beat free.

I would try to go with something as close to that as you can find. Much thinner and it will bow more than you like. In my case it is rock solid. With thinner material you could build some internal supports but that complicates it.
3. I started with a single pass on the table saw but that just didn't look right so I adjusted the fence a bit and made a second pass. Seems to work well with good flow through it.
4. Oh now you are getting personal! LOL I didn't use anything scientific when I did mine. The length of the overflow box was dictated by the size of the material I had on hand and I just cut the slot as long as I could while still leaving enough support at the ends. If the box were much longer, I would have cut multiple slots leaving intermediate supports in the middle. I have never calculated flow rates but my pump runs wide open and is rated at 1650 gal/hr. Some of that has been diverted to the skimmer and to the reactor but I ran it initially with the entire flow to the tank in testing.
5. I forget the exact dimensions but the holes are like 4 or 5 inches center to center. They can be more or less if you like. Just keep in mind that you need to be able to get your fingers in there later so more room helps. The 90 degree elbows in the box are not glued and I remove them at start up to help the air work out of the system and keep it running dead silent. I tried to get the holes as close to the top as I could so that the box didn't need to be any deeper.
6. Full coast-2-coast has big advantages in skimming all the surface of the tank. In my case, I didn't have 6' long acrylic so that stopped that. LOL The other disadvantage of a c-2-c is that it will shade the back wall of the tank. In my case, the right side of the tank is shaded a bit on the back wall limiting what I can put back there. In a full c-2-c that problem would be magnified.
7. I suppose it is very possible to crack the tank by bumping hard pipe. In my opinion, if I am that clumsy it doesn't much matter if it is hard pipe or hose. LOL Big advantages though to hose I think but it was a matter of cost for me. I didn't want to drop the extra cash on expensive hoses when PVC Pipe was so cheap. To make my build happen, I had to go cheap or it wasn't going to get built. If you do go with hoses, make sure they are not clear. If light can get in, algae will grown and you will have problems down the road.
Hope all that helps. Don't be afraid to throw out any more questions you might have.
Rich