I learned the hard way...once upon a time I had a 150 gal freshwater penisula tank with an acrylic false wall to create a spillover. I laminated acrylic to make a 5/8" thick sheet that i cut to the exact size and used a bit of pressure to suilicone it in. 9 months later the tank poped a seam on the end the acrylic was installed.
An additional note here would be to use a silicone adheasive rather than just a sealant for proper grip.