I use Fuel which needs to be refrigerated after opening, which makes it a no for me. I think the "Acro Power" product that Acroholic was talking about can actually be kept at room temp. The ELOS aminos come super concentrated and you dose them with an eye dropper. I don't know if they have a refrigeration requirement but if not I'd think you could just add them to your top off. I've heard that you need to use ELOS aminos as well as their protein skimmer additive to get the full effect.