Yes!
Edit: When I run a canister filter, I buy two sets of filtermedia, which makes changing out the media a whole lot quicker. Just open it up, take out the dirty media, put in the clean media, close it up and turn it back on.... Then you clean the dirty media and you're through for two weeks.
some people will tell you that you shouldn't change out all your media at once, but it's not an issue if you have live rock in your main tank.