I just used Fluke Tabs to treat my 300 gallon reef for clavularia (blue clove polyps). Anyone that has seen my tank knows they were everywhere. This is not a method for anyone to take lightly, as Fluke Tabs will kill leathers, tube worms, GSP, Xenia, and possibly prevent these from growing for years afterwards.
Mine was an absolute plague, and conventional methods like kalk paste, reef napalm (lye + water) would spot kill, but my rock is Totoka, very branchy with tons of openings, and you could not get it all, short of a complete tank teardown.
If Brisco has a few patches of GSP, then I'd try kalk or reef napalm before using Fluke Tabs. After Fluke Tab treatment, there are a
lot of water changes to do, and mechanical filtration to keep on top of, etc, as you can have a heckuva nutrient spike if you don't keep up on it.
In one way the cloves were attractive, but on the other hand, there was probably 4 square feet of them in the tank, and they surrounded my SPS bases and grew so densely between my zoas they almost prevented them from opening.
I don't know, but I also started to question the effect on the SPS of all the chemicals put off by such a single dominant species in my tank. I know they were affecting the ability of the SPS to encrust by blocking all the light around their edges, even though they did seem able to kill the cloves if they did encrust.
So what I am saying is this was a last chance option for me, so if you can do it any other way, I'd try that first. Fluke Tabs are near impossible to find in the US any more, so I had to import mine.
But all that said, here are some before and after pics.
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