Unfortunately, the upper floor is on a poured concrete basement wall. The concrete basement wall is fully under the sill plate on the upper wall, so it won't go through without a severe turn. There is also temperature to consider as the walls aren't really well insulated. Those issues aside, I wouldn't run through the wall due to concern over breakage/leaking. I wouldn't want to have to replace or repair an entire load bearing external wall if something drastic were to happen.
At this point, I will use a register sized slot that will have a panel that I can set between the pipes to cover the gap. That will also allow me to run the lines vertically.
