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Ok Jeremy, now you are just trying to be difficult! 
Yes you CAN calibrate your refractometer against two sources, just know that if it need to be, your refract is defunct and you would be better off getting a new one. You can calibrate it at the low end but it could be off at the high end, you can calibrate it at the high end but then it could be off at the low end. You should always check the two points atleast once just to make sure.

Yes you CAN calibrate your refractometer against two sources, just know that if it need to be, your refract is defunct and you would be better off getting a new one. You can calibrate it at the low end but it could be off at the high end, you can calibrate it at the high end but then it could be off at the low end. You should always check the two points atleast once just to make sure.