The pressure is greatest at the bottom of the tank, so that is where you want the most surface area. Thicker side panes will help to reduce bowing (especially on longer panes), but you need the additional surface area for silicone at the bottom of the tank. Another option is that you can use euro bracing around the bottom, it is just tricky since the silicone in the middle of the brace will never cure.
So, for example, my 100g tank that I built measures 54"x24"19". I built my tank entirely of 1/2" glass with 3.5" wide x 1/2" thick eurobracing. If I were to follow the calculators online, I might have been able to get away with 3/8" sides and 3/4" bottom (accounting for approximately 17.5-18" water depth). Since I already had a lot of 1/2" glass on hand, I decided to go with all 1/2". My bottom is raised approx. 1/8". My tank sits on a 1/4" thick closed cell foam yoga mat. I feel that the eurobracing gives me the additional surface area that I need at the bottom of the tank, but a 3/4" thick bottom would look much nicer if I decide later on to run bare bottom.