I have it in a mixing trashcan, with a heater and mixing pump, and it is always present. The Red Sea Pro suggests that you use it right after mixing it, which I have done. I have done that with IO and RC as well with no issues...just check the salinity. I typically use it and then mix more and leave until next use. I have three mixing trashcans, one with RODI water, another with Red Sea Pro, and another with RC. All three have a mixing pump and heater. I use the Red Sea Pro in my main tank and the RC in my other tank...sort of a 55 gallon frag tank (a long story...).