Well I'm hardly an authority on any of this - we've done this more or less as an experiment. I don't have "hard science" on this stuff - it's purely anecdotal based on our experiences with it, and with the other reactor that a former employee of mine built a few years ago.
Brian found some articles online about them, which prompted him to build this one - he had no prior experience with them.
As I mentioned, the reactor is offline right now - and late last week we downsized that system - but for the few months we ran it on the full sized system it worked quite nicely. When we get it back online, the system will be approximately 350 gallons (we took 4 tanks down - supporting structure was compromised - rust!)
I don't know if you could use one reactor and stack the media. I would think so, but I don't know. I've seen folks do that with larger reactors. Whether it would be effective or not, I do not know.
The drawbacks... can drop pH, which is why we run it through aragonite, to counteract that.
The articles Brian read also said to monitor for a sulfur smell - which can cause problems - he's not experienced that either. I believe that if there's a sulfur smell, flow-through is too fast.
Jenn